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实习医生日记之顽固失眠

实习医生日记之顽固失眠

今日去我院某教授跟门诊,有一位中年女性患者因“反复失眠20余年”来就诊。在此之前我并不知道真正意义上的熊猫眼,不过今日可真的见识到了,特拍了一张照片:

实习医生日记之—妊娠剧吐

实习医生日记之—妊娠剧吐

刘某,女,32岁,第一次怀孕,停经已12周。该患者停经的第九周开始出现恶心呕吐,开始时呕吐尚不多,3-5次每天。后来呕吐逐渐加重,7-8次每天,呕不能食,呕出食物及黄胆水。

实习医生日记之猪蹄脚

实习医生日记之猪蹄脚

组成 黄芪10克,党参(或太子参)10克,丹参10克,炒白术10克,薏苡仁15克,仙鹤草15克,白花蛇舌草15克,甘草5克。功能 益气活血,健运脾胃。主治 适用于治疗慢性萎缩性胃炎,或伴有肠上皮化生等

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研究确定黑人恶性乳腺癌生物标记物

字号:T|T|T
摘要:关键词乳腺癌生物标记物黑人妇女年月日讯生物谷根据最近一项研究表明在美国的非裔女性由于一种名为的蛋白含量过高而导致其有更高风险患有恶性乳腺癌这项由研究人员主导的研究认为蛋白含量与恶性乳腺癌发生有直接关系研究人员发现在一些恶性乳腺癌患者体内蛋白

关键词:乳腺癌,生物标记物,黑人妇女,hset

2013年12月16日讯 /生物谷bioon/ --根据最近一项研究表明,在美国的非裔女性由于一种名为hset的蛋白含量过高而导致其有更高风险患有恶性乳腺癌。这项由georgia state university研究人员主导的研究认为hset蛋白含量与恶性乳腺癌发生有直接关系。研究人员发现在一些恶性乳腺癌患者体内hset蛋白的表达量剧增,而此前也有研究表明hset的表达水平可能与肺癌和脑瘤有关。据此,负责这项研究的ritu aneja认为hset将有可能作为恶性乳腺癌疾病的生物标记物,研究人员可以通过分析hset的水平来判断病人患有乳腺癌的风险大小。

ritu aneja介绍这项研究是通过分析149名非裔美国女性和44名非西班牙裔白人女性体内hest水平后得出的。他们发现体内hset蛋白表达水平最高的乳腺癌患者其生存率远远低于hset表达量一般的患者。ritu表示这项研究将对未来的恶性乳腺癌研究以及新的生物标记物研发提供借鉴。(生物谷bioon.com)

详细英文报道:

african-american women who have high levels of a particular protein may be at risk for more aggressive breast cancer and poorer outcomes, according to new research from a georgia state university study.

the research, presented at the american association for cancer research conference on the science of cancer health disparities in racial/ethnic minorities and the medically underserved, found that increased levels of the protein hset were associated with worse breast cancer outcomes.

in triple-negative breast cancer--a particularly aggressive form of breast cancer that disproportionately afflicts african-american women--scientists have found that hset is upregulated. hset overexpression has previously been implicated in lung cancer metastasis to the brain.

"our data indicate that hset represents a potential new biomarker for poor breast cancer outcome among african-american women with the disease," said ritu aneja, associate professor of biology at georgia state university in atlanta, in a statement. "using this biomarker effectively could give oncologists critical new information and potentially save lives by allowing earlier recognition of more aggressive breast cancers in african-american women, with the subsequent use of more customized treatment regimens to better manage disease."

aneja and her team made their discovery after looking at breast tumor samples from 149 african-american women and 44 non-hispanic white women and testing for levels of hset. they found especially high levels--three times the amount--of hset in the tumor samples from african-american women compared to non-hispanic white women.

african-american women with the highest levels of hset found in their tumors were also three to four times more likely to have shorter overall survival, progression-free survival and metastasis-free survival when compared with african-american women who tested on the low end of levels for hset.

aneja says a biomarker to detect aggressive cancer earlier in african-american women could improve breast cancer care for this population since african-american women are more likely to be diagnosed with breast cancer at a younger age than non-hispanic white women and are more likely to have cancers that spread, reappear or cause death.

(责任编辑:lishuheng)

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